There have been multiple drug trails which have shown a marked improvement in individuals who have taken serotonin-reuptake inhibitors for the treatment of obsessive compulsive disorders. Aside from this tricyclic antidepressants have also been used in conjunction with serotonin-reuptake inhibitors. Studies have shown 40 to 60 percent of individuals show an improvement of symptoms when taking serotonin-reuptake inhibitors (Jenike, 2004).
However the relapse rate of these patients taking medications for obsessive compulsive disorder is quite higher than cognitive behavioral therapy. One study showed an astonishing 90% relapse rate among patients who received this form of therapy. There have been several trails which have attempted to augment the effect of serotonin-reuptake inhibitors. One such study used clonazepam which when used in combination with clomipramine or fluoxetine has shown some success. Numerous other agents have also been studied in combination with serotonin-reuptake inhibitors such as clonidine, tryptophan, pindolol, trazodone, and tramadol. Results are not conclusive or positive with few patients showing improvements in these studies (Jenike, 2004).