Thesis: Clinical Tests of Serotonin Syndrome

Sample Thesis Paper

The diagnosis of Serotonin syndrome is purely clinical. Diagnosis is dependent upon identifying the cause of the toxicity. The clinical features are highly variable and according to criteria. The diagnosis is made according to three major symptoms and two minor symptoms. History plays an important role in determination as onset is sudden with evidence of hyperflexia and clonus.

According to the criteria the major symptoms may be confusion, fever or hyperthermia, diaphoresis, myoclonus, hypertonia, tremors, shivering and hyperreflexia. The minor symptoms may be hyperactivity, agitation, insomnia, restlessness, tachycardia, tachypnoea, dyspnoea, hypotension or hypertension, flushing, diarrhea, Inco-ordination, mydriasis, acathisia and ataxia(Bijil, 2004).

Data regarding 5-HT2A Receptor Binding in Brain Regions of 22 healthy subjects aged 22-69 years old during PET scanning.

5-HT2A Receptor Binding

(DVratio-1)a

5-HT2A Receptor Binding

(DVratio-1)a

Correlation of Binding with Age (df=21) Correlation of Binding with Age (df=21) Receptor Loss Per Decade of Age
Brain Region Mean SD R p %
Gyrus Rectus 2.12 0.87 -0.80 <0.0001 19.5
Posterior Medial Pre-frontal cortex 2.25 0.79 -0.76 <0.0001 17.6
Hippocampus 0.63 0.25 -0.62 <0.0001 16.1
Occipital Cortex 2.42 0.87 -0.79 <0.0001 16.6
Anterior Cingulate 2.13 0.78 -0.81 <0.0001 18.3
Global Brain 1.99 0.80 -0.84 <0.0001 18.2

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