Sample Thesis Paper

Summary of Case

Ms. Jennifer Down, a 50 year old woman with a history of depression since 5 years was admitted to the hospital with complaints of fainting, flushed face and elevated blood pressure. Her condition was stabilized. According to the account she collapsed after drinking a cup of St. John’s Wort Tea. After she drank the tea her face became flushed and while walking she had a black out. She has no history of hypertension and has been prescribed Parnate (chemical name tranylcypromine) for the past two years for depression. No other significant signs or symptoms were present.

Diagnosis

According to the case history it is suspected that the patient has Serotonin syndrome also known as Serotonin Toxicity.

Introduction to Biochemistry

Serotonin

Serotonin or 5-hydroxytryptamine, 5-HT is synthesized by the decarboxylation and hydroxylation of the amino acid L-tryptophan. There are at least seven types of 5-hydroxytrptamine serotonin family receptors. Several of which are subdivided even further. After it is synthesized in the presynaptic neurons it is incorporated into vesicles until released for use. It binds to postsynaptic receptors to cause its effects. It then re-enters the cytoplasm where it is once again inserted into vesicles. It is then metabolized by monoamine oxidase subtype A to hydroxyindoleacetic acid(Bijil, 2004).

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